Although the role of AXL–GAS6 expression and signaling effects in lung cancer have been reported in recent years (Ishikawa et al. 2013; Shieh et al. 2005; Wimmel et al. 2001; Zhang et al. 2012), the role of AXL–GAS6 in brain metastases from lung cancer and its potential prognostic importance have not been well clarified. This evidence concerns the gene AXL and lung cancer.