Consistent with the previous report [20], RT-QUIC allowed the differentiation of DLB from other degenerative disorders, such as AD and prion diseases, as well as from non-degenerative cases, suggesting that r-αSyn is largely unaffected by the ability of other misfolded proteins, i.e., amyloid-β, tau, and PrPSc, to induce heterologous cross-seeding. This evidence concerns the gene MAPT and Alzheimer disease.