In current study, we investigated the effects of XLOC expression on GC cell phenotypes in vitro and demonstrated that ectopic expression of XLOC can significantly influence expression levels of multiple EMT related molecules including E-cadherin, N-cadherinand and Vimentin, which indicated that XLOC affected invasion and metastasis partly through epithelial-mesenchymal transition. Here, CDH1 is linked to gastric cancer.