Sustained hyperinsulinemia and hyperglycemia with compromised insulin/IRS2/FOXO1 signaling yields high expression of MTP and apoC-III with an overproduction of TG-VLDL1[52, 75-79] yet causes of compromised insulin/IRS2/FOXO1 signaling remain unclear. The gene discussed is FOXO1; the disease is Hyperinsulinemia.