In contrast, interruptions in the CTG expansions in myotonic dystrophy type I delay disease onset and suppress the muscular dystrophic phenotype (Musova et al., 2009), disruptions in the CGG repeats of fragile X mental retardation 1 (FMR1) protect carriers from premature ovarian failure (Bodega et al., 2006), and CAT insertions between CAG expansions in the ataxin-1 gene (ATXN1) prevent the development of the full SCA1 phenotype. The gene discussed is CASP3; the disease is primary ovarian failure.