Interestingly knockdown of Reelin, the glycoprotein absent in reeler mutant mice, impairs rats in the object recognition task, whereas Reelin overexpression can rescue deficits in the object recognition task in mouse models of Alzheimer's disease (Brosda et al., 2011; Pujadas et al., 2014). This evidence concerns the gene RELN and early-onset autosomal dominant Alzheimer disease.