SERPINE1 and coronary artery disorder: A pooled meta‐analysis shows the highest quantile (ie, tertile, quartile, or quintile) of blood PAI‐1 levels is associated with higher risk of CHD incidence compared with the lowest quantile (OR=2.17; 95% CI: 1.53, 3.07; Figure 2A) in an age‐and sex‐adjusted model.11, 12, 13, 14, 15, 16, 17, 18, 19, 22 The overall heterogeneity across studies is high (I2=71.5%, P<0.001; Figure 2A).