Finally, reports of microglia activation in angiogenesis (Arnold and Betsholtz, 2013) and recent reports of microglial contribution to elevated basic fibroblast growth factor (bFGF) expression in the CNS after injury (Fujimaki et al., 2016) (perhaps via the ERK pathway (Lu et al., 2007, Ibrahim et al., 2011)), suggest a potential mechanism for the reported anti-angiogenic effects of CoQ10 (Choi et al., 2011, Jung et al., 2009, Sachdanandam, 2008) and its potential as a therapeutic for the treatment of age-related macular degeneration. Here, FGF2 is linked to age-related macular degeneration.