in a population-based analysis, which showed that patients with LDL-C >4.9 mmol/L and no FH mutation had a 6-fold higher risk for CHD and those with both LDL-C >4.9 mmol/L and an FH mutation had a 22-fold higher risk compared to subjects with normal LDL-C and no mutation [10]. The gene discussed is FH; the disease is coronary artery disorder.