GWAS have also identified common variants in the locus that codes for phosphatidylinositol-3,4,5-trisphosphate-5-phosphatase 1, also known as SHIP1, which is encoded by the gene INPP5D. The AD-risk variant rs35349669 is associated with high gene expression in myeloid cells, and weak expression in brain tissues and neurons. The gene discussed is INPP5D; the disease is Alzheimer disease.