Whereas all four candidate genes (rsks-1, rheb-1, daf-15, and hpo-11) are strongly activated in the tumor strain shc-1;Is[daf-16::GFP] that carries a daf-2(+) allele, they were differentially regulated in daf-2(-) animals (Fig 5D). This evidence concerns the gene RHEBP1 and neoplasm.