PTEN and neoplasm: However, both shc-1;Is[daf-16::GFP], and shc-1;akt-1 only resulted in tumors in the presence of daf-2(+), and daf-18/PTEN(-) exacerbated shc-1;akt-1 tumor penetrance, but did not cause germline proliferation defects in either shc-1 or akt-1 alone.