Another rotenoid, boeravinone, reverses drug resistance by blocking BCRP/ABCG2-triggered drug efflux in breast cancer cells [32], and 6-deoxyclitoriacetal also showed excellent anti-tumor activity in SW620, KATO, ChaGo, BT474 and HepG2 cells [33]. The gene discussed is ABCG2; the disease is neoplasm.