It has been reported that ENO1 was up-regulated in various human cancers including gastric cancer [35, 36], glioma [37], breast cancer [38], lung cancer [39], head and neck cancer [40], endometrial carcinoma [41], pancreatic adenocarcinoma [42, 43], and Non-Hodgkin's Lymphomas (NHLs) [44]. This evidence concerns the gene ENO1 and central nervous system cancer.