Fibrinogen is a common component of fibrinogen/fibrin matrix surrounding tumor cells, serving as a scaffold for binding members of growth factor families, such as transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF) [22]. Here, VEGFA is linked to neoplasm.