RAI1 and Cognitive impairment: Alpha compression during re-entrainment is accompanied by memory impairments (Ruby et al., 2015) and, assuming that in Rai1+/- mice alpha is being compressed by 2.5 hr on a daily basis under LD12:12 conditions, might also have contributed to cognitive deficits reported for Rai1-compromised mice kept under these same lighting conditions (Bi et al., 2007; Huang et al., 2016).