Overexpression of SNAI1 in MDCK and many carcinoma cell lines led to the loss of cell–cell adhesion mediated by E‐cadherin, transformed the morphology of cells from epithelial to spindle‐like mesenchymal, and enhanced their migratory and invasive traits in vitro (Batlle et al., 2000; Cano et al., 2000). This evidence concerns the gene CDH1 and carcinoma.