This notion is supported by observations that induction of a fully mesenchymal state through overexpression of an EMT‐TF may lead to a loss of tumor‐initiating potential and thus the ability to colonize (Celià‐Terrassa et al., 2012; Ocaña et al., 2012; Ruscetti et al., 2015; Tsai et al., 2012). This evidence concerns the gene TF and neoplasm.