In keeping with that, the study carried out by Xu et al. showed that IL‐37 had protective effect on myocardial infarction microcirculation reperfusion injury, the possible mechanism may be to promote Treg cells, inhibit inflammatory reaction (decreased IL‐6 and TGF‐α) and the expression of CTLA‐4 and FoxP3 61. Here, IL37 is linked to myocardial infarction.