Interestingly, we found 23 genes whose expression were significantly altered by SV (P<0.05, unpaired t-test; Supplementary Data 12) and among them were well-known cancer-related genes CDKN2A (SV in 5 samples), PRKCA (SV in 3 samples) and EP300 (SV in 3 samples). The gene discussed is PRKCA; the disease is cancer.