LBK1 inactivation has been linked to increased HIF-1α signalling50, 51; however, a slight but statistically significantly lower expression of GLUT1 was detected in tumours with LKB1 mutations compared to LKB1 wild-type tumours (P=0.0076, Mann–Whitney u-test, Supplementary Fig. 18a). The gene discussed is HIF1A; the disease is neoplasm.