HIF1A and AIDS dementia complex: Furthermore, GSEA analysis of DEGs between TCGA lung SqCC and ADC cohorts identified a significant upregulation of known HIF-1α target genes41 (Supplementary Fig. 14h), which include GLUT1 and various glycolytic enzymes within the DEGs enriched in the TCGA lung SqCC cohort (Supplementary Fig. 14i).