Our analysis of SqCC and ADC KL tumours identified that higher p-AKT, p-4EBP1 and p-S6 expression in SqCC is associated with higher HIF-1α and GLUT1 expression in SqCC tumours compared to ADC tumours (Fig. 7c and Supplementary Fig. 16a). Here, AKT1 is linked to AIDS dementia complex.