Although previous studies have reported an increase in GLUT1-mediated aerobic glycolysis by EGFR, KRAS, BRAF or other frequent oncogenic mutations in ADC22, 47, 48, 49, our analysis found no significant increase in GLUT1 mRNA expression in ADC patients possessing KRAS, EGFR, BRAF, LKB1, PIK3CA or PTEN mutations compared to those who did not (Supplementary Fig. 18a). Here, PTEN is linked to AIDS dementia complex.