PIK3CA and non-small cell lung carcinoma: In addition, it has been shown that mTOR inhibitor MLN0128 attenuates HIF-1α and GLUT1 expression in NSCLC cell lines and the KL model of NSCLC, which is associated with decreased 18F-FDG uptake, further corroborating the regulation of PI3K/AKT/mTOR pathway signalling on GLUT1 expression through HIF-1α (ref. 30).