KRAS and neoplasm: The KL mice, in which oncogenic mutant Kras, KrasG12D, is expressed and tumour suppressor Lkb1 is deleted upon intratracheal inhalation of adenovirus-Cre, exhibit a full spectrum of NSCLC subtypes, allowing the characterization of different tumour types within the same mouse25, 28, 29 (Supplementary Fig. 5a).