We demonstrate that LKB1-null A549 cell line exhibits higher GLUT1 expression as compared to other ADC cell lines we tested, yet all SqCC cell lines except HCC2450 express considerably higher levels of GLUT1 than A549 cells (Fig. 2a,b), and SqCC xenograft tumours (HCC95 and HCC1588) exhibit significantly higher HIF-1α induction than A549 xenograft tumours (Supplementary Fig. 16c). This evidence concerns the gene STK11 and AIDS dementia complex.