In addition, vaccination with α-Sa strain elicited IgG cross-reactivity with a variety of coagulase-negative (CoN) Staphylococci species (Supplementary Fig. 8), supporting that α-Sa vaccine could be considered for broader applications, such as the prevention of device-associated health care-associated infections recognized as the most clinical relevant CoN-staphylococcal infections. The gene discussed is ARSA; the disease is staphylococcal infection.