They are located within blades 4–6 of SEMA β-propeller and overlap with the secondary binding site of the Listeria monocytogenes protein Internalin B. This antibody inhibited tumor growth in HGF-dependent preclinical models of glioblastomas [4] and pancreatic carcinomas [91], and showed good tolerability and satisfactory pharmacokinetic properties in Phase I studies [92]. Here, HGF is linked to neoplasm.