BRAF and melanoma: Interestingly, they demonstrated that, upon vemurafenib treatment of melanoma cells, the interaction between the DNA enhancer sequences MET + 63 kb and the MET transcription start site (TSS) significantly increased, suggesting an inducible chromatin looping downstream of BRAF inhibition [76] and identifying the transcription factor MITF as possible looping factor for the MET + 63 kb enhancer.