In another study, blocking the ER stress response circuitry triggered by oncolytic rhabdovirus infection by a small molecular inhibitor of serine/threonine protein kinase and endoribonuclease IRE1α, which was identified in a genome-wide siRNA screen, greatly enhanced cytotoxicity via caspase-2-induced apoptosis and increased oncolytic efficacy in refractory tumor models in mice [139]. This evidence concerns the gene ERN1 and neoplasm.