In other studies, human pancreatic and ovarian cancer cells display resistance against Rb-dependent oncolytic adenovirus, strongly correlating with intracellular levels of MxA, and acquired resistance to repeated oncolytic adenovirus injections in an intraperitoneal ovarian carcinoma model was associated with an increase in MxA as well as several other key ISGs in the tumors [103,104]. This evidence concerns the gene RB1 and ovarian carcinoma.