Moreover, the prevailing tumor interstitium is rich in soluble angiogenic factors, such as members of the vascular endothelial growth factor (VEGF) family [4], cellular growth factors, including endothelial growth factor (EGF), basic fibroblast growth factor (FGF), platelet-derived growth factor (PDGF) and pleiotrophic factors, particularly transforming growth factor (TGF) beta [5]. This evidence concerns the gene VEGFA and neoplasm.