TNF and neoplasm: Additionally, both tumor- and stromal cells secrete cytokines and chemokines, such as interleukin (IL) 6, IL 10, tumor necrosis factor (TNF) alpha, stromal cell-derived factor (SDF) 1, macrophage migration inhibitory factor (MIF) 1, which on one hand recruit more stromal and progenitor cells into the tumors and on the other hand curb the activity of antigen-presenting cells and anti-tumor T cells [6,7,8].