DSG2 and neoplasm: As DSG-2 is overexpressed in several types of solid tumors in contrast to CAR, oncolytic viruses containing fibers from B2 or B3 serotypes show enhanced infectivity on tumor cells compared to subgroup A, C, B1, D, E, F, and G. In addition, binding to DSG-2 seems to open the epithelial junctions between tumor cells and favor tissue penetration [5].