Successful isolation of MSCs from patients with MS has previously beenreported3, , , –7 although, as with studies ofmarrow, control groups have not always been age-matched and/or disease-free.Broadly, similar patterns of mesenchymal differentiation have beenreported,4, , –7 but only De Oliveira et al.7 reported increased senescence with alterations in the MS MSC secretome(reduced interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β)) andaltered gene transcription. This evidence concerns the gene TGFB1 and myeloid sarcoma.