Pathogenic variants in RYR1, TPM3 (MIM# 191030), TPM2 (MIM# 190990), ACTA1 (MIM# 102610), SEPN1 (MIM# 606210), LMNA (MIM# 150330), and MYH7 (MIM# 160760) genes can cause CFTD, with TPM3 being the most common cause of this form of myopathy (Clarke et al. This evidence concerns the gene RYR1 and myopathy.