HMOX1 and kidney disorder: In short, curcumin has been demonstrated to exhibit anti-inflammation properties in different kidney diseases models by reducing inflammatory molecules release (MCP-1, NF-κB, TNF-α, IL-1β, COX-2, and cav-1) and inducing the expression of anti-inflammation factors (HO-1, M6PRBP1, and NEDD4), suggesting that it could play a contributing role in preventing the initiation of renal fibrosis.