It has been demonstrated that curcumin treatment (100 mg/kg/day for 8 weeks, oral gavage) suppressed NF-κB activation, prevented inhibitor of NF-κB (IκBa) degradation, and decreased intercellular adhesion molecule-1 protein expression in streptozotocin- (STZ-) induced diabetic nephropathy rats [15], which was also reflected in LPS-induced kidney inflammation mice [20]. This evidence concerns the gene NFKB1 and diabetic kidney disease.