GD patients have up to 9% risk of developing PD.<h4>Case presentation</h4>We report two patients with GD that developed PD at different disease stages.<h4>Conclusion</h4>We reviewed the literature on the coexistence of PD and GD and speculate that the severity of symptoms may be related to the type of GBA mutation inherited. This evidence concerns the gene GBA1 and Parkinson disease.