KLRK1 and neoplasm: Preclinical studies have shown that resveratrol induces immunomodulatory effects, including the upregulation of NKG2D receptors on natural killer cells (NK) that it promotes the NKG2D-dependent killing of tumor cells [13, 14] and the induction of regulatory T cells (Treg) in the colonic tissues of mice exposed to colonic inflammatory stress [15].