It was observed that the CXC3R1 protein and mRNA expression is reduced in total monocytes from sepsis patients, whereas CX3CL1 concentration was elevated in serum, suggesting that monocytes from sepsis patients are retained in circulation because of CX3CL1 levels and CXC3R1 expression, preventing their recruitment to the focus of infection [37]. Here, CX3CL1 is linked to Sepsis.