PTEN and leukemia: One alternative regulator is c-Myc which controls the transcription of genes encoding glucose transporters and enzymes controlling glycolysis and glutaminolysis in T cells.8 Another key role for c-Myc is to control glucose flux through the hexosamine biosynthetic pathway which is also essential for the T lymphoma/leukemias driven by PTEN deletion.45 The importance of c-Myc and mTORC1 controlled pathways for malignant T cells would be one reason that an amino acid transporter such as SLC7A5 would also be important.