Increases in glucose, glutamine and transferrin uptake in immune activated normal T cells are regulated by c-Myc and mTORC1, the latter via control of expression of HIF1 complexes.4, 8, 23 High levels of c-Myc expression are characteristic of T-ALL either as a result of c-Myc translocations or NOTCH signaling.14, 15, 37, 38 Hence, wild-type and PTEN−/− non-transformed thymocytes had no detectable expression of c-Myc (Figure 3a) and NOTCH1 (Supplementary Figure 2a), whereas c-Myc protein was readily observed in primary PTEN−/− T-ALL cells (Figure 3a). This evidence concerns the gene HIF1A and acute lymphoblastic leukemia.