However, history of hypertension (adjusted OR 0.817, 9% CI 0.520–1.284, P = 0.381), ischaemic heart disease (adjusted OR 1.391, 95% CI 0.833–2.323, P = 0.208), hypoalbuminaemia (adjusted OR 1.019, 95% CI 0.752–1.381, P = 0.903), and the use of ACE I/ARBs (adjusted OR 1.574, 95% CI 0.928–2.668, P = 0.092), or beta blockers (adjusted OR 1.369, 95% CI 0.909–2.064, P = 0.133) lost their statistical significance in the multivariable analysis. The gene discussed is ACE; the disease is Hypoalbuminemia.