The hGH minigene-expressing transgenic mice with a reduced endogenous Gh production and a reduction in body growth described above15, 16, 18 also show perturbations in lipid metabolism (increased triglycerides, increased adipose tissue mass, liver steatosis and deregulated genes that take part in lipid metabolism) similar to our findings, despite the increased body size of the TgC6hp55 mice47. This evidence concerns the gene GH1 and Hepatic steatosis.