Table 1 shows a comparison of the clinical and biochemical characteristics of women with and without PCOS depicting typical metabolic and endocrine characteristics such as dyslipidaemia, increased insulin resistance, poorer beta cell function, higher diastolic and systolic blood pressure (SBP, DBP), higher luteinizing hormone (LH) and lower sex hormone binding globulin (SHBG) in women with PCOS. The gene discussed is SHBG; the disease is Insulin resistance.