The multivariate pattern of decreased Apo A1, HDL-C and HDL-phospholipids have been previously linked to inflammation-associated dyslipidaemia in obesity.45 This is corroborated by previous cross-sectional studies that found elevated CRP levels and increased low-grade chronic inflammation in PCOS women.46 These results suggest that PCOS women may indeed be at higher risk of cardiovascular diseases such as atherosclerosis. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.