There was no significant association between metastatic (M+) disease and TP53 mutation (p=1), MYCN amplification (p=0.15), or LCA pathology (p=0·67), or an association between sub-totally resected (R+) disease and TP53 mutation (p=1), MYCN amplification (p=1) or LCA pathology (p=0·41). Here, TP53 is linked to Leber congenital amaurosis.