Cancer immunoediting allows an immunologically sculpted tumor to begin to grow progressively in the escape phase until the lesion becomes clinically apparent and establishes an immunosuppressive microenvironment, and immunoediting also promotes tumor growth in which poorly immunogenic and immunoevasive transformed cells are key players along with CD8+ T cells, CD4+ Tregs, and PD-L1 [1]. This evidence concerns the gene CD274 and cancer.