For example, an aberrant autocrine bFGF circuit is a key component of downstream ERK1/2 activation and tumor aggressiveness in NSLC [57], breast cancer [58], head and neck squamous cell carcinoma [59], and mesothelioma [36] cells, and mediates resistance to RTK inhibitors [60]. This evidence concerns the gene MAPK3 and head and neck squamous cell carcinoma.