Nursing-home residents, male gender, critical illness (PBS ≥4) on arrival at the ED, initial syndromes of severe sepsis or septic shock on arrival at the ED, fatal comorbidities (McCabe classification), polymicrobial bacteremia, K. pneumoniae, Pseudomonas species, or ESBL-producing EKP bacteremia, bacteremia pneumonia, underlying neurological diseases or liver cirrhosis, thrombocytopenia, or elevated serum levels of C-reactive protein were more frequently noted in patients who died. This evidence concerns the gene CRP and bacterial infectious disease with sepsis.