As the autophagy regulatory gene LC3-II is required for ERK phosphorylation in NIH/3 T3 cells [31] and DEPP-induced autophagy is triggered by ROS accumulation, we wondered whether DEPP mediates ERK phosphorylation and p21 induction via ROS and LC3-II conversion in neuroblastoma cells. This evidence concerns the gene DEPP1 and neuroblastoma.