In agreement with aforementioned studies, our lab has shown that high responding dairy animals, based on dermal fibroblast IL-8 production in response to TLR ligands, have greater tissue damage and neutrophil influx into the mammary gland post-infection and a slower return to pre-infection milk production levels in response to both Staphylococcus aureus (S. aureus) and E. coli mastitis, without any benefit to their ability to clear bacteria [16, 17]. The gene discussed is CXCL8; the disease is infection.