INSR was substantially down-regulated in the tumor samples (median = 0.58; range = 0.01–471.75; RQ < 1 in 84.2% of cases), as was IGFBP-3 (median = 0.52; range = 0.05–2.96; RQ < 1 in 80.7% of cases). This evidence concerns the gene IGFBP3 and neoplasm.