KLK3 and posterior cortical atrophy: In addition to the previously reported association between IGF-1R and T2E expression indicating that patients harboring the fusion gene show higher IGF-1R mRNA levels than T2E-negative cases (p-value = 0.008, Fisher’s test) [24], IGF-1 expression was decreased in advanced PCa cases (Gleason score 7 or greater, p-value < 0.0001; PSA 10 ng/ml or greater, p-value = 0.01; clinical stage (cT) 3a or greater, p-value = 0.001; pathological stage (pT) 3 or greater, p-value = 0.005; lymphnode pathological stage (pN) 1 or greater, p-value < 0.0001; Fisher’s or chi-square tests).