First, translational regulation of ILEI by TGF-β/AKT2/hnRNP-E1 was originally described in a breast cancer model and we did not observe any evidence of AKT-mediated regulation of ILEI expression (S2 Fig), and while we observed an effect of TGF-β on ILEI expression this was at the mRNA level (Figs 1–3 and data not shown). This evidence concerns the gene TGFB1 and breast cancer.