UGGT1 and infection: In the absence of infection, UGGT1 and CNX were shown to colocalize in the ER (Fig 6A, panels 5 and 21), but some UGGT1 began deploying out of the ER to colocalize with the 3D viral polymerase upon EVA71 infection (Fig 6A, panels 20 and 22), to the point where little UGGT1 remained in the ER with CNX.