We showed that STC1 could promote cell apoptosis and arrest G1/S transition, and STC1 promoted cell apoptosis via NF-κB phospho-P65 (Ser536) by PI3K/AKT, IκBα and IKK signaling in cervical cancer cells, thus having the potential to provide a novel direction for the therapy and prevention of cervical cancer. The gene discussed is RELA; the disease is cervical carcinoma.