NFKB1 and melanoma: found that RIP1 was frequently up‐regulated in human melanoma and played an oncogenic role, and RIP1 promoted melanoma cell proliferation through the activation of NF‐κB. Notably, the ubiquitination of RIP1 was also prominently increased in melanoma cells, which was responsible for the high expression of RIP1 and constitutive activation of NF‐κB. Through the blockage of TNFαR1 stimulation and RIP1 ubiquitination, the activity of NF‐κB and the growth of melanoma were impeded 88.