SIAH2 and melanoma: It was indicated that MEN could bind with Siah2 on Ser39 of its substrate‐binding domain (SBD) to attenuate its self‐ubiquitination, leading to the increased expression of siah2 substrates PHD3 and Sprouty2, which subsequently attenuated the expression levels of HIF‐1a and pERK, and block melanoma tumorigenesis 136.