Cdt1, which mediates DNA replication and accumulates in S phase of cell, and promotes the cancer cell death, is stabilized by MLN4924 through blocking the function of CRL1‐Skp2 and the formation of Cul4‐Rbx1‐Ddb1‐Cdt2 complex 129.During a phase I trial of MLN4924 in melanoma, 37 patients received different dosages of MLN4924. The gene discussed is SKP2; the disease is melanoma.