CXCR7 overexpression may affect disease progression by stimulating proliferation, invasion, migration, adhesion, and angiogenesis of GC through β‐arrestin‐dependent downstream signalings, including Akt, ERK1/2, p38 MAPK, JAK2/STAT3, and stress‐activated protein kinase (SAPK) pathways 91, 93, 94, 95, 96. This evidence concerns the gene MAPK3 and gastric cancer.