Reciprocally, YAP1 could modulate EMT‐TF activity, as described for endothelial cells in which YAP1 interacts with SMAD complexes and modulates TGF‐β‐induced upregulation of Snail1, Snail2 and Twist1 (Zhang et al., 2014a), and in breast cancers, in which ZEB1 turns into a transcriptional activator by interacting with YAP1 (Lehmann et al., 2016) (Fig. 2B,C). The gene discussed is SNAI1; the disease is breast carcinoma.