These data can be complemented by observations in cancer cells, in which ZEB1 induces LOXL2‐mediated collagen stabilization and deposition in the extracellular matrix (Peng et al., 2017), and Snail1 and Twist1 expression affects the activity of metalloproteases on the extracellular compartment (Ota et al., 2009; Weiss et al., 2012; Zhao et al., 2011) (Fig. 2A,C). This evidence concerns the gene TWIST1 and cancer.