The male‐specific decline in fasting insulin level in ACA‐treated mice hints that the altered pattern of glucose spikes produced by ACA may lead to improved insulin sensitivity in males, with less effect in females, and that this protection against insulin resistance might in turn contribute to the sexual dimorphism in longevity effect (Harrison et al., 2013) and in the age‐associated hypothalamic inflammation demonstrated in this study. This evidence concerns the gene INS and Insulin resistance.