For instance, mutations in MFN2, OPA1, DNM1L, and MFF (encoding mitochondrial fission factor) cause Charcot–Marie–Tooth disease type 2A (MIM# 609260), dominant optic atrophy (MIM# 165500), and severe infantile encephalomyopathies (MIM# 614388; 617086), respectively. Here, MFF is linked to autosomal dominant optic atrophy.