Production of bioactive IL1β by the NLRP3 inflammasome requires a two‐step process involving initial priming from the toll‐like receptors (TLR) by lipopolysaccharide (LPS) and subsequent activation by hyperglycemia, saturated fatty acids such as palmitate, ROS, oxidized LDL, or cholesterol crystals. Here, IL1B is linked to Hyperglycemia.