NLRP3 and Hyperglycemia: Production of bioactive IL1β by the NLRP3 inflammasome requires a two‐step process involving initial priming from the toll‐like receptors (TLR) by lipopolysaccharide (LPS) and subsequent activation by hyperglycemia, saturated fatty acids such as palmitate, ROS, oxidized LDL, or cholesterol crystals.