F2RL3 and dengue disease: In our proteome analysis, proteins related to platelet activating signaling including PAR4 (F2RL3), G protein subunits (GNA12 and GNA14) and p38 MAPK (MAPK14) were increased in platelets from patients with dengue (blue dots in Fig 2B and S2D Table), potentially contributing to increased platelet activation during dengue infection.